Changes in Alveolar Macrophage Function During Acute Lung Injury

Sichuan University

Status: Unknown

Conditions: Acute Lung Injury

Treatments: Procedure: Bronchoscopy

Study type: Observational

Funder types: Other

Identifiers

NCT02693912

wch-150718

Details and patient eligibility

About

In this study, the investigators aim to observe the change in alveolar macrophage function during acute lung injury.

Full description

Alveolar macrophages are tissue-resident or recruited cells with key functions in recognition of pathogens, initiation of host defensive ang protective inflammation,and in clearance of pathogens from the airways. However, macrophages are also responsible for efficient clearance of apoptotic neutrophils, termed efferocytosis, which is a prerequisite for the timely resolution of inflammation. In this study, the investigators aim to observe the change in alveolar macrophage function during acute lung injury.

Enrollment: 25 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients in ICU with diagnosed ALI under mechanical ventilation

Exclusion criteria

• Patients with cardiac dysfunction, using steroid drugs or other drugs can that affect efferocytosis

Trial design

25 participants in 2 patient groups

acute lung injury

Description:

Patients with a diagnosis of acute lung injury (ALI) under mechanical ventilation.Patients will underwent bronchoscopy for bronchoalveolar lavage fluid.

Treatment:

Procedure: Bronchoscopy

control

Description:

Patient under mechanical ventilation without any lung diseases. Patients will underwent bronchoscopy for bronchoalveolar lavage fluid.

Treatment:

Procedure: Bronchoscopy