Changes in Attentional Control After a Focal Seizure. (ATTENTIONEPIF)

University Hospital, Lille

Status: Enrolling

Conditions: Frontal Lobe Epilepsy; Temporal Lobe Epilepsy; Others Subtypes

Treatments: Other: All included subjects

Study type: Observational

Funder types: Other

Identifiers

NCT06466681

2022_0762

Details and patient eligibility

About

Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age superior to 18 and under 80
• Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up
• Normal global cognitive performance (standard progressive Raven matrices score > 5th percentile)
• Be affiliated to the social security system
• Have signed an informed consent

Exclusion criteria

• Pregnancy or breastfeeding
• Not able to give consent (Article 1121-8 of the CSP)
• Vulnerable person
• Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP)
• Guardianship
• Have a high probability of not respecting the protocol or of abandoning the study
• Absence of any epileptic seizure recorded during the hospitalization
• Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure.