Changes in Cardiovascular Hemodynamics During Peritoneal Dialysis

University of Aarhus

Status: Terminated

Conditions: Peritoneal Dialysis

Treatments: Drug: Icodextrin (dialysate); Drug: Physioneal (dialysate) 1.36% and 2.27%

Study type: Interventional

Funder types: Other

Identifiers

NCT00119990

AA20050009

Details and patient eligibility

About

During peritoneal dialysis, water is removed from the body. This sometimes occurs at rates of up to 500 ml/h. During shifts with dialysate with high glucose content, an increase in blood pressure has been described. The effect upon central hemodynamics is unknown. The researchers are investigating the effects of low and high glucose dialysate and icodextrin on cardiac output, stroke volume, pulse rate and blood pressure. The researchers have hypothesized that the effects seen are induced by vasopressin.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Peritoneal dialysis patients

Exclusion criteria

• Insulin dependent diabetes mellitus
• AV-fistula, cardial arrhythmia persistence, or severe cardiac and lung disease
• Recent infectious disease
• Severe psychiatric disease
• Hypersensitivity to icodextrin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)