Changes in Central Arterial Pressure When Comparing Nifedipine/Labetalol for Routine Hypertension Control in Pregnancy

Saint Louis University (SLU)

Status

Withdrawn

Conditions

Hypertension

Treatments

Other: Labetalol

Other: Nifedipine

Study type

Observational

Funder types

Other

Identifiers

NCT02912910

27464

Details and patient eligibility

About

To study central blood pressure changes caused by commonly used high blood pressure medications in pregnancy.

Full description

Central blood pressures in addition to pulse wave velocity will be attained prior to medication, and then every 30 minutes for 4 hours (total of 9 readings). Sphygmomanometer readings will be completed at the same time (total readings 9). These readings are all related to the study.

Nursing will have the opportunity to to record the routine sphygmomanometer readings for their routine vitals if they chose to do so.

Their participation will be complete after the 4 hour assessment is complete.

Sex

Female

Ages

14 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Singleton pregnancy
Women with hypertensive disease in pregnancy who are currently being treated with nifedipine xl or labetalol

Exclusion criteria

Multiple pregnancy
Currently on multiple anti-hypertension medications
Narcotic use
Irregular heart rhythms or arrhythmias
Peripheral arterial disease, leg artery disease
Reynaud's phenomena
Intense cold/hypothermia
If there is a wound at location of where central arterial cuff would be placed or tonometer for carotid assessment
Known sensitivity to labetalol or nifedipine
Severe tachycardia (>120)
Greater than 1st degree heart block
Severe asthma
Congestive heart failure or heart disease
Lupus
Inability to adequately monitor BP
Currently receiving magnesium sulfate