Changes in Cerebral Blood Flow (CBF) in Prone and Sitting Position Before and After GSP-block and Before and After Epidural Blood-patch: A Substudy of NCT03652714

University Hospital Bispebjerg and Frederiksberg

Status

Withdrawn

Conditions

Sphenopalatine Ganglion Block

Postdural Puncture Headache

Treatments

Procedure: Ganglion sphenopalatine block with local anesthetic administered on study GSPB-2018

Procedure: Ganglion sphenopalatine block with placebo administered on study GSPB-2018

Study type

Interventional

Funder types

Other

Identifiers

NCT03966547

GSPB-2018-SUB

Details and patient eligibility

About

The purpose of this optional sub-study to GSPB-2018 (NCT03652714) is to evaluate the changes in cerebral blood flow (CBF) under different conditions to understand if postdural puncture headache is caused by changes in the cerebral blood flow and if treatment normalises that change.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Study Population:

Subjects who have consented to participate in GSPB-2018 will be approached for participation in this sub-study. Subjects who have consented to participate in GSPB-2018 are not required to participate in this sub-study.

Inclusion Criteria:

Age > 18 years
Patients with postdural puncture headache defined as moderate to severe postural headache (VAS >= 30mm) after lumbar puncture or accidental dural puncture during epidural insertion with an onset within 3 days following the puncture.
Lack of headache remission within 1 day after dural puncture and after treatment with fluids, caffeine and paracetamol
Patients who have given their written informed consent for participation in the study and substudy after fully understanding the protocol content and limitations.

Exclusion Criteria:

Patients who cannot cooperate to the study
Patients who does not understand or speak Danish
Allergy to the drugs used in the study
Has taken opioids within 12 hours prior to intervention
No possible transcranial window on transcranial doppler. If not possible to find a useable window to get measurement the patient will be excluded and replaced with another patient.