Changes in Cerebral Oxygenation and Cognitive Functions

Zonguldak Bulent Ecevit University

Status: Completed

Conditions: Hypotension; Controlled; Cognitive Dysfunction

Treatments: Drug: Nitroglycerin; Drug: Esmolol

Study type: Observational

Funder types: Other

Identifiers

NCT04948957

2013-81-03/09

Details and patient eligibility

About

The present study aimed to assess the influence of nitroglycerin and esmolol-induced hypotension on cerebral oxygen saturation by using near-infrared spectroscopy and postoperative cognitive function in patients undergoing nasal surgery.

Enrollment: 40 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• written informed consent
• patients with ASA physical status of I-II
• aged 18-65 years

Exclusion criteria

• Age under 18 or above 65
• ASA > II
• coagulation disorders
• history of cardiovascular and cerebrovascular disease
• poor Blood Pressure control
• anemia, pregnancy, addiction to opioids
• body mass index (BMI) > 35
• intraoperative systolic BP < 65 mmHg
• surgical duration less than 30 minutes or more than 160 minutes
• need for an intraoperative sympathomimetic drug and the use of other hypotensive drugs
• preoperative Mini-Mental State Examination (MMSE) score of 23 or less.

Trial design

40 participants in 2 patient groups

esmolol (Group E)

Treatment:

Drug: Esmolol

nitroglycerin (Group N)

Treatment:

Drug: Nitroglycerin