Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism

National and Kapodistrian University of Athens

Status: Completed

Conditions: Hypoparathyroidism Postprocedural

Treatments: Drug: calcium carbonate and alphacalcidol

Study type: Observational

Funder types: Other

Identifiers

NCT04146259

1387/08-12-2015

Details and patient eligibility

About

To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism

Full description

Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy.

Based on the development of biochemical hypocalcemia (cCa < 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism.

Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels

Enrollment: 109 patients

Sex: Female

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Indication for total thyroidectomy

Exclusion criteria

• parathyroid disorders, chronic kidney disease (eGFR< 60 ml/min), treatment with antiosteoporosis drugs, rheumatic disease and history of long term (>1 month) or current corticosteroid use

Trial design

109 participants in 2 patient groups

group A

Description:

Control

Group B

Description:

Post-surgical hypoparathyroidism

Treatment:

Drug: calcium carbonate and alphacalcidol