Changes in Iron Markers Following Iron Loading in Hemodialysis Patients

Papageorgiou General Hospital

Status and phase: Completed; Phase 4

Conditions: Anemia in Chronic Renal Disease

Treatments: Drug: iron sucrose

Study type: Interventional

Funder types: Other

Identifiers

NCT00308490

48/31-1-2005

Details and patient eligibility

About

The purpose of this study is to describe alterations of serum ferritin, transferrin saturation, soluble transferrin receptor, % hypochromic erythrocytes, % reticulocytes, reticulocyte hemoglobin content after iron loading in hemodialysis patients.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hemodialysis for three months minimum
• stable epoetin dose for two months minimum
• serum ferritin concentration < 1000 ng/ml
• transferrin saturation < 50%
• parathormone concentration < 800 pg/ml

Exclusion criteria

• hemoglobin concentration > 13g/dl
• serum ferritin concentration < 20 ng/ml
• vitamin B12 and/or folic deficiency
• other hematologic disease than anemia
• cancer
• hypothyroidism
• infectious disease

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)