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Changes in Nasal Patency With Changes in Posture, Temperature, Humidity and Nasal Patency Seen by Acoustic Rhinometry

The University of Chicago logo

The University of Chicago

Status and phase

Completed
Phase 4

Conditions

Mucosal Congestion

Treatments

Procedure: Acoustic rhinometry (procedure)

Study type

Interventional

Funder types

Other
Industry

Identifiers

Details and patient eligibility

About

To study nasal physiologic responses to changes in posture, temperatures, humidity and nasal patency with acoustic rhinometry.

Full description

The purpose of this study was to utilize acoustic rhinometry to assess changes in nasal patency after alterations in posture, unilateral mechanical obstruction, temperature, and humidity.

Eight healthy adult volunteer subjects underwent acoustic rhinometry under the following conditions: 1) upright, sitting position (control), 2) supine position, 3) left lateral recumbent position, 4) one nostril mechanically blocked, 5) icepack on neck, 6) drinking cold water, 7) drinking hot water, 8) nasal nebulizer, 9)oxymetazoline decongestant.

Changes in nasal cavity volumes were detected by acoustic rhinometry after alterations in posture, unilateral mechanical obstruction, temperature, and humidity. Nebulizer treatment and hot water ingestion caused a significant decrease in nasal volume. The nose was able to adapt to environmental and physiological changes in order to maintain a consistent total nasal volume.

Enrollment

15 patients

Sex

All

Ages

18 to 58 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy volunteers, 18-58 years old

Exclusion criteria

  • Any nasal symptoms in the last 3 weeks
  • Marked septal deviation/polyposis/infection
  • Any history of allergy, asthma or immunodeficiency
  • Any systemic condition or infection (e.g., hypertension/diabetes/heart, liver, thyroid or kidney disease
  • Any spine or neck condition that would not allow normal postures
  • Pregnancy

Trial design

Primary purpose

Diagnostic

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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