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Changes in Optical Coherence Tomography Leakage Mapping in Diabetic Macular Edema After Conbercept Treatment

W

Wuhan University

Status

Unknown

Conditions

Diabetic Macular Edema

Study type

Observational

Funder types

Other

Identifiers

NCT04254536
OCT-LOR-DME

Details and patient eligibility

About

Eyes with diabetic macular edema requiring conbercept treatment will be followed up for one month. Before treatment, one week after treatment and one month after treatment, the eyes will be examined by optical coherence tomography (OCT) and optical coherence tomographic angiography (OCTA). The changes of macular edema will be observed and analyzed by OCT leakage mapping software, and the relationship between the changes of macular edema and visual acuity will be analyzed.

Full description

  1. Research purpose:

    After one month follow-up, we will observe whether OCTleakage mapping can be used as a biomarker to predict the prognosis of DME eyes, and will observe the effect of Conbercept on improving edema and visual acuity of DME eyes.

  2. Subjects Number of subjects planned to be recruited: 35

Inclusion criteria:

  1. Age ≥ 18
  2. Diabetic macular edema eyes treated with conbercept for the first time in 1 week
  3. Informed consent of patients and signing of informed consent

Exclusion criteria:

  1. High myopia
  2. Macular diseases affecting vision
  3. Vitreous hemorrhage requiring surgery
  4. Patients with anterior segment neovascularization
  5. Eye or periocular infection
  6. Optic neuropathy and glaucoma
  7. Periphlebitis, ophthalmic ischemic syndrome, uveitis, coat's disease, FEVR and other retinal diseases
  8. Ametropia and cataract surgery
  9. In 3 months, in addition to this treatment of conbercept, other anti VEGF treatment, laser treatment or vitreoretinal surgery were performed
  10. Other systemic diseases can not complete follow-up

Enrollment

35 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

1)Age ≥ 18

  1. Diabetic macular edema eyes treated with conbercept for the first time in 1 week

  2. Informed consent of patients and signing of informed consent

Exclusion criteria

1)Myopia ≥ 6.0D

  1. Macular diseases affecting vision

  2. Vitreous hemorrhage requiring surgery

  3. Patients with anterior segment neovascularization

  4. Eye or periocular infection

  5. Optic neuropathy and glaucoma

  6. Periphlebitis, ophthalmic ischemic syndrome, uveitis, coat's disease, FEVR and other retinal diseases

  7. Ametropia and cataract surgery

  8. In 3 months, in addition to this treatment of conbercept, other anti VEGF treatment, laser treatment or vitreoretinal surgery were performed

  9. Other systemic diseases can not complete follow-up

Trial contacts and locations

0

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Central trial contact

Jingwen Jiang; Hongmei Zheng, MD

Data sourced from clinicaltrials.gov

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