Changes in Renal and Splanchnic Oxygenation During Ibuprofen Treatment for Patent Ductus Arterious

Zekai Tahir Burak Women's Health Research and Education Hospital

Status

Completed

Conditions

Ductus Arteriosus, Patent

Treatments

Device: Near-infrared spectroscopy (NIRS)

Study type

Observational

Funder types

Other

Identifiers

NCT01251939

n7860088

Details and patient eligibility

About

Patent ductus arterious(PDA)is frequently seen and potentially pathologic in preterm infants. Near-infrared spectroscopy is a simple bedside tool to analyse the changes in the renal and splanchnic tissue oxygenation index and fractional tissue oxygen extraction and may be helpful to measure effects of ibuprofen treatment for PDA in preterm infants.

Full description

Patent ductus arterious (PDA) is the most common cardiovascular abnormality in preterm infants.There are clear associations between a PDA and decreased renal and splanchnic blood flow. The aim is to monitor, using near-infrared spectroscopy, the effect of ibuprofen on the fractional tissue (renal and mesenteric) oxygen extraction (FTOE) in preterm newborns during ibuprofen of the treatment PDA.

Enrollment

30 patients

Sex

All

Ages

2+ days old

Volunteers

No Healthy Volunteers

Inclusion criteria

Gestational age <32 weeks and <1500 g
Echocardiographic evidence of hemodynamically significant patent ductus arterious

Exclusion criteria

Major congenital anomalies
Intraventricular hemorrhage of grade 3 within the previous 24 hours
Serum creatinine level 1.5 mg%,serum urea nitrogen concentration >50 mg%,
Platelet count 60 000/mL3, a tendency to bleed (defined by the presence of hematuria, blood in the endotracheal aspirate, gastric aspirate, or stools and/or oozing from puncture sites)
Hyperbilirubinemia necessitating exchange transfusion