Changes in Renal Papillary Density After Hydration Therapy in Calcium Stone Formers

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Completed

Conditions: Urolithiasis

Treatments: Other: Oligomineral water

Study type: Interventional

Funder types: Other

Identifiers

NCT03343743

6118/13

Details and patient eligibility

About

Patients with recurrent calcium oxalate stones undergoing endourological procedures for renal stones at our institution from June 2013 to June 2014 were considered eligible for enrolment. Enrolled patients underwent a baseline unenhanced CT scan before the urological procedure; after endoscopic removal of their stones, the patients were instructed to drink at least 2 L/day of a hypotonic, oligomineral water low in sodium and minerals (fixed residue at 180°C <200 mg/L) for at least 12 months. Finally, the patients underwent a follow-up unenhanced CT scan during hydration regimen.

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing endourological procedures for renal stones
• Recurrent stone disease
• Calcium oxalate stones (>50% of the stone made of calcium oxalate)

Exclusion criteria

• Systemic conditions causing stones (hyperparathyroidism, intestinal malabsorption, renal tubular acidosis)
• Non-calcium oxalate stones

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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25 participants in 1 patient group

Hydration

Other group

Description:

Patients were instructed to drink at least 2 L/day of a hypotonic, oligomineral water low in sodium and minerals (fixed residue at 180°C \<200 mg/L) for at least 12 months

Treatment:

Other: Oligomineral water