Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer

Memorial Sloan Kettering Cancer Center (MSK)

Status

Enrolling

Conditions

Colorectal Carcinoma

Colorectal Neoplasms

Colorectal Cancer

Treatments

Behavioral: QoL Questionnaires

Diagnostic Test: Hormone biomarker analysis

Study type

Observational

Funder types

Other

Identifiers

NCT04812912

21-035

Details and patient eligibility

About

The purpose of this study is to find out how cancer treatments (chemotherapy and/or radiation therapy) affect reproductive and sexual health in people with early onset colorectal cancer. The study researchers will observe and track changes in hormone levels and in sexual and reproductive health in people with early onset colorectal cancer. This information will help researchers know more about how cancer treatments affect reproductive and sexual health, including the ability to have children (fertility).

Enrollment

120 estimated patients

Sex

All

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

18-40 years of age and premenopausal (female) or 18-50 years of age (male) at time of diagnosis
Histologic diagnosis of colorectal adenocarcinoma
Able and willing to participate in the informed consent process
Eligible for curative adjuvant or neoadjuvant therapy for colon or rectal cancer
Willing and able to complete protocol questionnaires
Rectal patients only: Individuals who will be receiving chemotherapy, followed by chemoradiotherapy (ChemoRT)

Exclusion criteria

Prior systemic treatment for this malignancy
Active or prior secondary malignancy
History of ovarian resection (if female)
Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception until the termination of gestation, confirmed by a positive hCG laboratory test.