Changes in Resting Metabolic Rate Following Orthopedic Surgery

University of Kansas

Status: Enrolling

Conditions: Metabolism; Disorder, Postprocedural; Resting Metabolic Rate; Post Operative Nutrition

Treatments: Other: Post-surgical nutrition, hydration, RMR and body composition assessments; Other: Pre-surgical nutrition, hydration, RMR, and body composition assessments

Study type: Observational

Funder types: Other

Identifiers

NCT06107959

STUDY00150689

Details and patient eligibility

About

This project is intended to determine the magnitude and duration of RMR changes in patients receiving orthopedic surgery. The result will help to guide postoperative nutrition recommendations in patients receiving orthopedic surgery.

Full description

Surgery produces a catabolic response in the body that shifts metabolism from glucose to fat and protein. Despite no studies examining ACLR, studies of other orthopedic surgeries demonstrate increased postoperative energy expenditure, as well as a shift to beta-oxidation. Additionally, in most patients, these changes reverted to baseline within six weeks, although a subset of patients did not return to baseline until beyond 12 weeks.

This project will improve our understanding of magnitude and duration of RMR changes following orthopedic surgery, and the subsequent perioperative dietary suggestions that should be made to improve patient outcomes. Currently, postoperative dietary suggestions are not surgery nor patient specific. Determining how orthopedic surgery effects RMR will help to personalize perioperative treatment, rehabilitation, and recovery.

Better understanding the change in RMR following orthopedic surgery and implementing more accurate dietary modifications will help to ensure positive outcomes and control of infection following orthopedic surgery.

Enrollment: 100 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any individual over 15 undergoing an orthopedic surgery.

Exclusion criteria

• Pregnant female
• < 15 years old

Trial design

100 participants in 2 patient groups

Male

Description:

50 male subjects undergoing orthopedic surgery.

Treatment:

Other: Pre-surgical nutrition, hydration, RMR, and body composition assessments

Other: Post-surgical nutrition, hydration, RMR and body composition assessments

Female

Description:

50 female subjects undergoing orthopedic surgery

Treatment:

Other: Pre-surgical nutrition, hydration, RMR, and body composition assessments

Other: Post-surgical nutrition, hydration, RMR and body composition assessments