Changes in Serum Fibroblast Growth Factor 21 (FGF21) Levels Correlated With Exercise

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Status: Completed

Conditions: Sedentary Lifestyle

Treatments: Other: Supervised Exercising

Study type: Interventional

Funder types: Other

Identifiers

NCT01512368

48024 (Other Grant/Funding Number)

REF173

Details and patient eligibility

About

We evaluated the effect of two weeks of intensive supervised physical activity in serum fibroblast growth factor 21 (FGF21) levels.

Full description

Comparative and longitudinal study. Anthropometric and biochemical evaluation were done before, 1hr and 4hr after a bout of exercise and repeated after two weeks of daily supervised exercise. We studied sedentary young healthy women. A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks. The Department of Endocrinology and Metabolism at the INCMNSZ performed all biochemical laboratory measurements using standardized procedures.

Enrollment: 82 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women
• Aged 18 to 35 years old,
• Body mass index (BMI) <30 kg/m2
• Without contraindication for exercising

Exclusion criteria

• Metabolic syndrome
• Diabetes
• Dyslipidemia
• Hypertension
• Asthma
• Thyroid disease
• Treated with fibrates, beta agonists or blockers
• History or current arrhythmias, murmurs, cardiomegaly, or treatment for cardiovascular diseases -
• Contraindications for exercise testing were also considered as exclusion criteria (see references)

Trial design

82 participants in 1 patient group

Supervised exercising

Experimental group

Description:

A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks to participants.

Treatment:

Other: Supervised Exercising