Changes of Tear-film Lipid Layer Thickness and Ocular Aberration After Treatment of Meibomian Gland Dysfunction

Yonsei University

Status: Completed

Conditions: Meibomian Gland Dysfunction

Treatments: Drug: Treatment of Meibomian gland dysfunction

Study type: Interventional

Funder types: Other

Identifiers

NCT02618304

1-2015-0012

Details and patient eligibility

About

In this study, investigator aim to evaluate the changes of tear-film lipid layer thickness and ocular aberration after treatment of meibomian gland dysfunction. In case of stage 3 or 4 meibomian gland dysfunction, participants will be treated using conventional treatment modalities. Before treatment and after 1 and 2 months of treatment, a variety of ophthalmic examination, tear-film lipid layer thickness, and ocular aberration are going to measured and compared.

Enrollment: 45 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. age over 19 years old, with moderate to severe Meibomian gland dysfunction.

Exclusion criteria

1. patients with history of previous ocular or intraocular surgery
2. ocular infection, non dry eye ocular inflammation, ocular allergy, autoimmune disease
3. history of intolerance or hypersensitivity to any component of the study medications
4. wearing contact lenses during the study period, presence of current punctal occlusion
5. pregnancy, lactating women, and children

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 1 patient group

moderate to severe meibomian gland dysfunction

Experimental group

Treatment:

Drug: Treatment of Meibomian gland dysfunction