Changes of the Neuronal Activity in the Subthalamic Nucleus Under Remifentanil Sedation During Stereotactic Electrode Implantation

Hadassah Medical Center

Status: Unknown

Conditions: Effect of Remifentanil; Movement Disorders

Treatments: Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT00588926

221107-hmo-ctil

Details and patient eligibility

About

Deep brain stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who has to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the basal ganglia.

The purpose of this study is to detect possible changes in the electrical activity of the basal ganglia related to remifentanil sedation. electrical activity of single neurons will be recorded before, during and after sedation.

Enrollment: 20 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with movement disorder, who are candidates for implantation of deep brain stimulation electrode.

Exclusion criteria

• Suspected difficult intubation
• history of sleep apnea
• known allergy for remifentanil

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

A

Experimental group

Description:

The patients get a period of sedation with remifentanil, before, during and after which, the changes in the electrical activity of the Basal Ganglia is recorded.

Treatment:

Drug: Remifentanil