Changing the Vulnerable Brain: A Neuromodulation Study in Alcohol Dependence

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Status and phase: Completed; Phase 3

Conditions: Alcohol Dependence

Treatments: Device: Repetitive Transcranial Magnetic Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT02557815

EA1027 (Other Grant/Funding Number)

91713354 (Other Grant/Funding Number)

Details and patient eligibility

About

This current project investigates the effect of a single session of right dlPFC repetitive transcranial magnetic stimulation on emotion regulation abilities and craving in alcohol dependent patients and healthy controls.

Enrollment: 80 patients

Sex: All

Ages: 21 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Alcohol Dependence
• Currently abstinent

Exclusion criteria

• psychoactive medication
• not eligible for MRI (metals or claustrophobia)
• (familial) history of epilepsy
• current psychiatric disorders (besides alcohol dependence)

Trial design

80 participants in 2 patient groups

Active Repetitive Transcranial Magnetic Stimulation (rTMS)

Experimental group

Description:

Repetitive Transcranial Magnetic Stimulation: Active 10hz stimulation over the right dorsolateral Prefrontal Cortex (dlPFC)

Treatment:

Device: Repetitive Transcranial Magnetic Stimulation

Sham stimulation

Sham Comparator group

Description:

Repetitive Transcranial Magnetic Stimulation: sham stimulation over the right dlPFC

Treatment:

Device: Repetitive Transcranial Magnetic Stimulation