Characterisation of Circadian Rhythm in Autistic Spectrum Disorder

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Autistic Disorder

Treatments: Other: Control functional exploration; Other: Autistic functional exploration

Study type: Interventional

Funder types: Other

Identifiers

NCT01984944

P081103

2009-011842-24 (EudraCT Number)

Details and patient eligibility

About

Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors. Results from genetic studies reveal one pathway associated with susceptibility to ASDs, which includes synaptic cell adhesion molecules. Among the factors that could modulate this pathway are the genes controlling circadian rhythms. Sleep disorders and low melatonin levels are frequently observed in ASDs. Thus investigator will characterize the circadian rhythms of patients with ASD and search for circadian rhythms genes polymorphisms.

Enrollment: 42 patients

Sex: All

Ages: 6+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with autistic spectrum disorders
• At least 6 years old
• Membership of a social security scheme
• Informed consent signed by the patient or both holders of parental authority if the subject is a minor, or by a guardian if the subject is under guardianship

Exclusion criteria

• Recent sleep symptoms
• Incapacity to keep rested for 24 hours

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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42 participants in 2 patient groups

Autistic Patient

Other group

Description:

* 50 adults * 25 childs

Treatment:

Other: Autistic functional exploration

Controls

Other group

Description:

* 50 adults * 25 childs

Treatment:

Other: Control functional exploration