Characterisation of Fractionated Electrograms Critical for Maintenance of Atrial Fibrillation (AF) (CAFE AF)

Barts & The London NHS Trust

Status: Completed

Conditions: Atrial Fibrillation

Treatments: Procedure: catheter ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT00894400

09/H0703/6

Details and patient eligibility

About

The purpose of this study is to characterise which fractionated electrogram morphologies are important to target in the catheter ablation of atrial fibrillation.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with persistent AF listed for first time catheter ablation

Exclusion criteria

• age < 18 years
• pregnancy
• contraindications to procedure
• recent myocardial infarction, coronary intervention, or cardiac surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Targeting of most fractionated electrograms first

Experimental group

Description:

During catheter ablation of AF patients will have fractionated electrograms targeted. In the experimental group the fractionated electrograms believed to be most critical will be targeted first.

Treatment:

Procedure: catheter ablation

Targeting least fractionated electrograms first

Active Comparator group

Description:

During catheter ablation of AF fractionated electrograms are targeted. In this arm the least fractionated electrograms will be targeted first.

Treatment:

Procedure: catheter ablation