Characteristic of Intestinal Flora in Male Elderly With Small Intestinal Bacterial Overgrowth (IFOSIBO)

Chinese PLA General Hospital (301 Hospital)

Status: Unknown

Conditions: 16s rRNA; Elderly; Small Intestinal Bacterial Overgrowth; Male

Treatments: Other: SIBO

Study type: Observational

Funder types: Other

Identifiers

NCT03659175

RZhang

Details and patient eligibility

About

We will focus on the intestinal flora structure, risk factors and clinical features of male elderly with SIBO in our study.

Full description

Our previous study had found that the prevalence rate of small intestinal bacterial overgrowth(SIBO) in male elderly was high up to 63.1%. In the recent years, SIBO has been found be associated not only with abdominal symptoms such as abdominal distention, pain and so on, but also with various diseases such as diabetes, Alzheimer's disease, joint pain, chronic prostatitis, fatty liver, liver cirrhosis etc. SIBO has significant impact on the health of elderly. Methane and hydrogen lactulose breath test(LBT) is effective and noninvasive for the diagnosis of SIBO. High throughput sequencing is a leading technique for the study of intestinal microflora.

Although more and more studies have focused their concern on the intestinal flora now, few SIBO-related studies are available in elderly patients. But we have found SIBO was very popular in the elderly. The conflict between high prevalence rate of SIBO in elderly and very few relevant studies is barrier to study of pathophysiology, early diagnosis and treatment of SIBO in elderly adults.

So in our study, we will apply LBT and high throughput sequencing technique to study the intestinal flora structure, risk factors and clinical features of male elderly patients with SIBO. And further, we will try to develop standard treatment for elderly patients with SIBO.

Enrollment: 40 estimated patients

Sex: Male

Ages: 65 to 98 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• no use of antibiotics in the past 1 month, no use of prokinetic drugs and probiotics in the past 1 week

Exclusion criteria

• active inflammation, cardiac insufficiency, respiratory insufficiency, hepatic insufficiency, renal insufficiency, cirrhosis, thyroid diseases, Crohn disease, ulcerative colitis, hepatobiliary and pancreatic disease

Trial design

40 participants in 2 patient groups

male elderly with SIBO

Description:

male elderly who was diagnosed as SIBO via 'lactulose breath test' (LBT). At the same time, they meet the following criteria: 1. no use of antibiotics in the past 1 month. 2. no use of prokinetic drugs and probiotics in the past 1 week. 3. without these diseases: active inflammation, cardiac insufficiency, respiratory insufficiency, hepatic insufficiency, renal insufficiency, cirrhosis, thyroid diseases, Crohn disease, ulcerative colitis, hepatobiliary and pancreatic disease.

Treatment:

Other: SIBO

male elderly without SIBO

Description:

male elderly without SIBO after 'lactulose breath test'. At the same time, they meet the following criteria: 1. no use of antibiotics in the past 1 month. 2. no use of prokinetic drugs and probiotics in the past 1 week. 3. without these diseases: active inflammation, cardiac insufficiency, respiratory insufficiency, hepatic insufficiency, renal insufficiency, cirrhosis, thyroid diseases, Crohn disease, ulcerative colitis, hepatobiliary and pancreatic disease.