Characteristics of Eosinophilic Gastritis, Enteritis, and Colitis in a Multi-Site Cohort

Cincinnati Children's Hospital Medical Center

Status: Completed

Conditions: Eosinophilic Colitis; Eosinophilic Gastroenteritis; Eosinophilic Gastritis; Eosinophilic Esophagitis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02897271

5U54AI117804-03 (U.S. NIH Grant/Contract)

2016-4349

Details and patient eligibility

About

The purpose of this study is to investigate features of patients with Eosinophilic Gastrointestinal Disorders (EGIDs) other than Eosinophilic Esophagitis (EoE) alone, including Eosinophilic Gastritis (EG), Eosinophilic Gastroenteritis (EGE), and Eosinophilic Colitis (EC).

Full description

This retrospective chart review study will analyze the demographics, medical history, clinical features, and pathological data of patients with Eosinophilic Gastrointestinal Disorders (EGIDs) other than Eosinophilic Esophagitis (EoE) alone, including Eosinophilic Gastritis (EG), Eosinophilic Gastroenteritis (EGE), and Eosinophilic Colitis (EC).

Enrollment: 381 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of an EGID including EG, EGE, and/or EC. Subjects with EoE can be included if they also have another EGID.
• Clinical symptoms of gastrointestinal dysfunction.
• Findings of increased eosinophils on tissue biopsy at the time of diagnosis, before treatment initiated.
• Exclusion of other causes of gastrointestinal eosinophilia.

Exclusion criteria

• Gastrointestinal eosinophilia caused by another disorder.
• Diagnosis of EoE without another EGID.
• Insufficient medical record or pathology data available to support an EGID diagnosis.