Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study (COHIRnational)

University of Bonn

Status: Enrolling

Conditions: Hypophosphatasia

Treatments: Diagnostic Test: Second alkaline phosphatase measurement

Study type: Observational

Funder types: Other

Identifiers

NCT06574282

MED2-202002

Details and patient eligibility

About

Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis

Full description

Acronym: Expansion:

HPP =Hypophosphatasia COHIR ="Characteristics of Hypophosphatasia in Adult Patients in Rheumatology" ALPL =Alkaline Phosphatase

Enrollment: 720 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Written informed consent
• Age > 18 years
• Clinical suspicion of hypophosphatasia
• Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening

Exclusion criteria

• Failure to meet the inclusion criteria listed above

Trial design

720 participants in 2 patient groups

Persistant hypophosphatasemia

Treatment:

Diagnostic Test: Second alkaline phosphatase measurement

Transient hypophosphatasemia (Control group without hypophosphatasia)

Treatment:

Diagnostic Test: Second alkaline phosphatase measurement