Characteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and Osteoporosis (MEDADIPO)

University Hospital, Lille

Status: Completed

Conditions: Osteoarthritis, Knee; Prosthesis User

Treatments: Procedure: tissue

Study type: Observational

Funder types: Other

Identifiers

NCT03678831

2017_59

2018-A00660-55 (Other Identifier)

Details and patient eligibility

About

Obesity and other associated complications promote the development and the progression of osteoarthritis. The subcutaneous and abdominal fat release several factors that alter bone and the cartilage. The role of the marrow fat in close connection with bone has not been defined yet, whereas cellular and animal models indicate that this fat depot modifies bone and cartilage.

The aim of the study is to define if the marrow fat produces more joint-altering factors by comparison with subcutaneous fat. This fat depot can be characterized from removed pieces during the prosthetic surgery of the knee. Measuring before surgery the body weight, waist and hip circumferences, blood pressure, glucose, insulin and lipids in blood will also allow to determine if obesity and/or type 2 diabetes make this fat more dangerous for the joint. Such research will allow the elaboration of new therapeutic strategies in osteoarthritis.

Enrollment: 45 patients

Sex: Female

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Post-menopausal woman
• with a symptomatic knee osteoarthritis requiring prosthesis
• able to handle general anaesthesia
• having given her consent
• able to understand the constraints associated with the study
• with health insurance
• able to understand the French language

Exclusion criteria

• with refusal to participate to the study

• more than 85-year-old

• with bone pathologies other than osteoarthritis or osteoporosis

• with active infection

• with evolving cancer

• with haematopoietic pathologies such as haemoglobin pathologies

• with thyroid pathologies

• with type 1 diabetes

• with anti-osteoporotic treatments (bisphosphonates, strontium ranelate, teriparatide, denosumab) except calcium and vitamin D supplementation or hormone replacement.

• with replacement of prosthesis

• with previous surgery at the surgery site

  --with a current participation to another study

• with guardianship

• with deprived liberty

Trial design

45 participants in 1 patient group

Arthritic patients with knee prosthetic replace

Description:

Arthritic post-menopausal patients with knee prosthetic replacement Each patient is her own control since the two cell types are compared within the same patient The main criteria is based on a comparison of two cell types from the same patient. The secondary criteria are based on a comparison of cell types according to a grouping of patients according to different metabolic parameters.

Treatment:

Procedure: tissue