Characteristics of Primary and Plasmatic Hemostasis in Preeclampsia

Goethe University

Status: Unknown

Conditions: Platelet Function; Coagulation Disorder, Blood

Treatments: Diagnostic Test: Aggregometry, Monitoring of plasmatic hemostasis

Study type: Observational

Funder types: Other

Identifiers

NCT03149250

Hemostasis_Preeclampsia

Details and patient eligibility

About

The study aims to investigate the impact of preeclampsia on hemostasis.

Full description

In comparison to healthy pregnant women and non-pregnant woman, this study analyses parameters of primary hemostasis and plasmatic coaguation in preeclamptic pregnant woman. Detailed analyses of the platelet function is performed using the Multiple Electrode Aggregometry, detailed analyses of the plasmatic coagulation syste is performed by isolated coaguation factor analyses and conventional coagulation analyses.

Enrollment: 60 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Platelet count > 100 / nll
• In study group and control group 1: Week of Pregnancy: 35-40
• in control group 2: healthy, not pregnant woman

Exclusion criteria

• Hereditary coagulopathy
• Missing content of the patient / proband
• Eclampsia
• HELLP syndrome
• CRP > 1 mg/dl
• Fever (> 38°C)

Trial design

60 participants in 3 patient groups

Pregnant Preeclampsia

Description:

Pregnant between 35th and 40th week of pregnancy Preeclampisa Intervention: Aggregometry, Monitoring of plasmatic hemostasis: Aggregometry and conventional coagulation testing after blood sampling in the context of routinely performed blood sampling

Treatment:

Diagnostic Test: Aggregometry, Monitoring of plasmatic hemostasis

Pregnant No-Preeclampsia

Description:

Control Group 1 Pregnant between 35th and 40th week of pregnancy No Preeclampsia Healthy Intervention: Aggregometry, Monitoring of plasmatic hemostasis: Aggregometry and conventional coagulation testing after blood sampling in the context of routinely performed blood sampling

Treatment:

Diagnostic Test: Aggregometry, Monitoring of plasmatic hemostasis

Not Pregnant

Description:

Control group 2 Healthy and not pregnant control group Intervention: Aggregometry, Monitoring of plasmatic hemostasis: Aggregometry and conventional coagulation testing after blood sampling.

Treatment:

Diagnostic Test: Aggregometry, Monitoring of plasmatic hemostasis