Characterization and Differential Diagnosis of Vertebral Osteomyelitis

Asan Medical Center

Status: Completed

Conditions: Vertebral Osteomyelitis

Study type: Observational

Funder types: Other

Identifiers

NCT01125839

AVOMS

Details and patient eligibility

About

Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus. The aim of this study is to describe the clinical features and microbiological/radiological characteristics of patients with vertebral osteomyelitis, and investigate the useful tips for the differential diagnosis of vertebral osteomyelitis.

Full description

Besides description of characteristics of patients with vertebral osteomyelitis, we also will investigate the usefulness of 16S rRNA gene sequence analysis of biopsy specimen. MRI findings during the antibiotic treatment will be monitored and compared for the differential diagnosis of meningitis.

Enrollment: 100 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Symptoms or signs consistent with spinal column infection
• MRI findings suggestive of infection
• Antibiotic treatment for vertebral myelitis

Exclusion criteria

• Patients already treated more than 2 weeks for osteomyelitis in transferring hospital

Trial design

100 participants in 1 patient group

Spondylitis

Description:

Patients who checked spine MRI for back pain