Characterization and Epigenetics of Post-Partum Preeclampsia

Duke University

Status: Terminated

Conditions: Post Partum Pre-eclampsia

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02935556

PRO00104636

Details and patient eligibility

About

This study will recruit women with post partum pre-eclampsia and match them to controls without postpartum pre-eclampsia to identify an epigenetic signature that is specific to women with post partum pre-eclampsia to help characterize the underlying pathophysiology of post partum pre-eclampsia.

Full description

Preeclampsia (PEC) is a heterogeneous disease that complicates 5-8% of pregnancies. Approximately 10% of PEC patients will present with post-partum PEC without having developed the syndrome during the pregnancy (PP-PEC). Management of post-partum preeclampsia (PP-PEC) is challenging because many women do not seek care until neurologic symptoms result from severe-range elevated blood pressure. The pathogenesis and clinical characteristics of PP-PEC are understudied and poorly understood. Identifying clinical risk factors and biomarkers of PP-PEC would help to identify women at risk.

Enrollment: 12 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Post partum pre-eclampsia

Matching based on:

• maternal age (years +/-3)
• BMI (+/-5 points)
• Ethnicity
• Mode of delivery
• Gestational age at delivery (+/7 days)
• Smoking status

Exclusion criteria

• Intrapartum pre-eclampsia

Trial design

12 participants in 2 patient groups

post partum pre-eclampsia

Description:

women with normal deliveries followed by post partum pre-eclampsia within 1 month of delivery.

Treatment:

Other: no intervention

controls

Description:

women with normal deliveries and normal post part courses who match the post partum pre-eclampsia women in age, BMI, smoking status, gestational age and race/ethnicity.

Treatment:

Other: no intervention