Characterization and Evaluation of Diagnostic Biomarkers for Tuberculosis

Yonsei University

Status: Completed

Conditions: Active Tuberculosis

Study type: Observational

Funder types: Other

Identifiers

NCT01269268

4-2010-0213

Details and patient eligibility

About

There was no sensitive and specific biomarker for tuberculosis infection, disease progression and predicting the prognosis of treatment. Therefore, the investigators aimed to investigate and evaluate the newer biomarker for the diagnosis of TB infection. To investigate the new biomarker for TB infection, the investigators will recruit the participants including active TB patients, healthy household contacts, healthy community control.

Enrollment: 270 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• active TB patients : diagnosed with active TB through the microbiologic examination, imaging findings
• healthy control : no history of TB treatment, no respiratory symptoms, no evidence of active infectious disease including TB on chest X-ray, no history of close contacts of active pulmonary TB patients

Exclusion criteria

• pregnant woman
• positive result of human immunodeficiency virus examination

Trial design

270 participants in 2 patient groups

active tuberculosis

Description:

active TB patients : diagnosed with TB through microbiologic examination

healthy control

Description:

healthy control : no evidence of respiratory disease, no respiratory symptoms, and no history of close contact of active pulmonary TB patients