Characterization and Prediction of Atrial Fibrillation-caused Adverse Events After Hospital Discharge for Cardiac Surgery (MATRICeS)

Mass General Brigham

Status: Enrolling

Conditions: Death; Atrial Fibrillation; Stroke, Acute

Treatments: Procedure: Cardiac surgery

Study type: Observational

Funder types: Other

Identifiers

NCT03466125

2017P002261

Details and patient eligibility

About

The purpose of the research is to identify the frequency and severity of adverse events related to atrial fibrillation that occur after discharge from hospital where the patient underwent cardiac surgery.

The Specific Aims of the proposed study are to:

1. Identify the predictors of postoperative atrial fibrillation after discharge from hospital.
2. Identify the frequency of readmission to hospital, or other resource use such as Emergency Department or outpatient visit, for the treatment or prophylaxis of postoperative AF and consequent stroke or bleeding outcomes.
3. Identify the risks for stroke, death and other morbidity in patients after cardiac surgery and the effect of postoperative AF upon subsequent stroke or bleeding outcomes.

Enrollment: 25,000 estimated patients

Sex: All

Ages: 20 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent cardiac surgery in Massachusetts between 2012 - 2016

Exclusion criteria

• surgical procedures that do not include coronary artery bypass graft surgery, aortic valve surgery or mitral valve surgery;
• surgical procedures that include MAZE surgery, or pulmonary vein isolation, ventricular assist device, heart transplantation, congenital heart surgery, bacterial endocarditis, cardiac trauma, cardiac tumor, ventricular septal defect repair, left ventricular aneurysm repair, pulmonary thromboendarterectomy, sub-aortic stenosis resection or surgical ventricular restoration;
• surgical procedures on patients that have undergone MAZE surgery, AF ablation procedures, pulmonary vein isolation or left atrial appendage resection or ablation (such as Watchman devices).

Trial design

25,000 participants in 1 patient group

Adult patients who underwent cardiac surgery in Massachusetts

Description:

No interventions. A retrospective cohort study of patients who underwent cardiac surgery in Massachusetts in calendar years 2012 - 2016.

Treatment:

Procedure: Cardiac surgery