Characterization and Progression of Minor Phenomena in Parkinson's Disease (PD)

University of Rochester

Status: Completed

Conditions: Parkinson Disease; Hallucinations; Delusion; Parkinson Disease Psychosis

Treatments: Other: Observation of minor phenomena

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT05240339

STUDY00003440

Details and patient eligibility

About

Parkinson's disease psychosis encompasses a range of symptoms, including minor phenomena, frank hallucinations, and delusions. Minor phenomena include passage hallucinations (fleeting sense of a person, animal or object passing in the periphery), presence hallucinations (feeling of nearby presence), and illusions (misrepresentation of external stimuli). Some forms of PD psychosis may be progressive. The primary objective of this study is to:

1. To determine the cumulative probability of developing hallucinations or delusions over time in individuals with PD minor phenomena followed for 36 months.

Enrollment: 38 patients

Sex: All

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinson's disease (as determined by Movement Disorders Society diagnostic criteria for clinically probable Parkinson's disease)
• Parkinson's disease minor phenomena
• ≥30 years of age
• Proficient in English
• Willing and able to provide informed consent

Exclusion criteria

• Any current or prior history of formed hallucinations or delusions
• Current or prior treatment with an antipsychotic medication (regardless of indication)
• Diagnosis of mania with psychotic features, bipolar or related disorder, depression with psychotic features, or a psychotic disorder
• Unable or unwilling to complete study activities
• Any medical or psychiatric comorbidity that, in the opinion of the investigator, would compromise study participation

Trial design

38 participants in 1 patient group

PD participants with minor phenomena

Treatment:

Other: Observation of minor phenomena