Characterization of Auditory Processing Involved in the Encoding of Speech Sounds (PRODIPRICIDE)
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About
The ability to encode the speech signal is determined by ascending and descending auditory processing. Difficulties in processing these speech signals are well described at the behavioral level in a specific language disorder. However, little is known about the underlying pathophysiological mechanisms. The assumption is that we should observe a degradation of the signal provided by the ear in the deaf subject while in case of specific language impairment it would be a phonemic disorder (possibly linked to a processing disorder auditory). The two population groups should therefore have different abnormalities of their central auditory process - which could be modified by the target remediation for each group.
Enrollment
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Ages
Volunteers
Inclusion criteria
For all subjects:
- native French speaker
- no medical treatment for behavior or neurological disorders
- normal or corrected vision
- right-handed
- normal otorhinolaryngology examination
- valid affiliation to social security
- no participation to another research study
For the normal-hearing subjects
- normal tonal hearing thresholds
- normal tympanometry
For the subjects without specific language impairment
- aged from 6 ro 40
- normal school attendance without scholastic retardation
- normal intellectual level
- normal for age reading skills
- no delayed speech (expression & production)
For the children with specific language impairment
- aged fom 8 to 18
- persistent specific literacy difficulties with reading levels at least 18 months behind that of their peers
- normal intellectual level
For the hearing impaired subjects
- age from 18 to 70
- first auditory rehabilitation
- bilateral and symmetric hearing loss (±10 dB) with hearing thresholds between 0 and 25 dB at 0.25 kilohertz, 0 and 35 dB at 0.5 kilohertz, 0 and 50 dB at 1 kilohertz, 25 and 70 dB at 2 kilohertz, 25 and 80 dB at 3 kilohertz, 30 and 80 dB at 4 kilohertz
Exclusion criteria
- non signed assent
- treatment for depression, epilepsy, Parkinson's or alzheimer's disease during more than 6 months
- physical health deficiency
- mental retardation
- neurological or psychiatric disease incompatible with testing procedure
For children
- known problem of hearing loss or chronic middle ear disease whic compromized the hearing status
- schooling in a foreign language
- foreign language spoken at home with both parents
Trial design
Primary purpose
Allocation
Interventional model
Masking
25 participants in 6 patient groups
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Data sourced from clinicaltrials.gov
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