Characterization of Bovine Adrenal Medulla as a New Surrogate Model of Non-histaminergic Itch

Aalborg University

Status

Completed

Conditions

Itch

Treatments

Drug: A-967079 and BAM8-22 application after 5 minutes.

Drug: Vehicle and BAM8-22 application.

Drug: A-967079 and BAM8-22 application

Drug: A-967079 application.

Study type

Interventional

Funder types

Other

Identifiers

NCT05249387

N-20190062 5th project

Details and patient eligibility

About

With this experiment, the experimenter wish evaluate the role of TRPA1 on non-histaminergic itch induced by BAM8-22

Full description

With this experiment, the experimenter wish evaluate the role of TRPA1 on non-histaminergic itch induced by BAM8-22 2 (Bovine Adrenal Medulla), which is found naturally in the human body and which has proved to evoke itch. To evaluate the role of TRPA1 it will be used a TRPA1 antagonist (A-967079)

Enrollment

22 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy men and women
18-60 years
Speak and understand English

Exclusion criteria

Pregnancy or lactation
Drug addiction defined as any use of cannabis, opioids or other drugs
Previous or current history of neurological, dermatological, immunological musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.)
Moles, wounds, scars or tattoos in the area to be treated or tested
Lack of ability to cooperate •
Current use of medications that may affect the trial such as antihistamines and pain killers.
Skin diseases
Consumption of alcohol or painkillers 24 hours before the study days and between these - Acute or chronic pain •
Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)