Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation

University of Pennsylvania

Status and phase: Enrolling; Early Phase 1

Conditions: Ventricular Tachycardia

Treatments: Drug: Stellate Ganglion Block

Study type: Interventional

Funder types: Other

Identifiers

NCT05377216

851066

Details and patient eligibility

About

Prospective cohort study evaluating the electrophysiologic and biochemical effects of stellate ganglion block in patients with ventricular tachycardia.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Planned catheter based VT ablation
• Age at least 18 years

Exclusion criteria

• Pregnancy
• Contraindication to SGB or VT ablation
• Hypersensitivity of local anesthetic of amide type
• Hemodynamic instability during the procedure prior to the study protocol

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Stellate ganglion block

Experimental group

Description:

All subjects will undergo stellate ganglion block during their VT ablation procedure

Treatment:

Drug: Stellate Ganglion Block