Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease (HPGAIT)

Henri Mondor University Hospital

Status: Active, not recruiting

Conditions: Hydrocephalus; Walking, Difficulty; Movement Disorders; Parkinson Disease; Diagnoses Disease; Gait Ataxia

Treatments: Diagnostic Test: Dynamic stability measurement

Study type: Observational

Funder types: Other

Identifiers

NCT05998473

2023-A01762-43

Details and patient eligibility

About

This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant monitoring criteria in usual care.

Full description

Walking disorders in normal pressure hydrocephalus are manifested by slowing and ataxic gait, similar to disorders in Parkinson's disease. No studies in the literature have focused on advanced measures of dynamic stability in hydrocephalus at normal pressure, compared to Parkinson's disease, on large samples. The Laboratory of Analysis and Restoration of Movement, located in a Neurorehabilitation Department, provides quantitative data on gait and in particular dynamic stability as part of additional assessments to help patients follow up. Since 2010, people with normal pressure hydrocephalus or Parkinson's disease regularly benefit from these assessments. Retrospective analysis of all these data would help to better characterize motor disorders in hydrocephalus at normal pressure, by discriminating them from those associated with Parkinson's disease. It would lead to the definition of relevant indices to be used for patient follow-up.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age >18 years
• Patient who performed a walking test in the Laboratory Analysis and Restoration of Movement
• Diagnosis of normal pressure hydrocephalus or Parkinson's disease

Exclusion criteria

• Levodopa drugs administrated during a delay of 12 hours before walking test
• Presence of an other neurologic disease or of any disease associated with motor disorders in lower limb.

Trial design

150 participants in 2 patient groups

Normal pressure hydrocephalus

Description:

Patients with a diagnosis of normal pressure hydrocephalus and who performed a gait analysis in laboratories

Treatment:

Diagnostic Test: Dynamic stability measurement

Parkinson's disease

Description:

Patients with a diagnosis of Parkinson's disease and who performed a gait analysis in laboratories

Treatment:

Diagnostic Test: Dynamic stability measurement