Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery (GLYNO)

Centre Hospitalier Universitaire, Amiens

Status: Unknown

Conditions: Capillary Leak Syndrome

Treatments: Biological: plasma

Study type: Observational

Funder types: Other

Identifiers

NCT02853682

PI2015_843_0027

Details and patient eligibility

About

The glycocalyx is a layer of proteins and complex sugars covering the endothelium of vessels. Its role as capillary filtration control is important. In case of alteration of the glycocalyx, experimental models and some clinical studies show an increased capillary leak responsible for interstitial edema. The analysis of glycocalyx in routine care is important to guide volume expansion. Indeed, the literature provides evidence about the poor prognosis of excess water and its impact on organ. This analysis challenge is to justify filling solution of choice according to the characteristic of this capillary leakage.

Full description

Extra corporeal circulation and aortic clamp induce ischemia-reperfusion damages.

Vascular damages are represented by first glycocalyx, a layer of endovascular vessel proteoglycans, responsible for fluid permeability and secondly by nitro oxygen liberation responsible for vascular tonus.

The investigators suppose that both functions are impaired after cardiac surgery.

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• cardiac surgery

Exclusion criteria

• auricular fibrillation
• endocarditis
• aortic dissection
• end stage chronic renal disease

Trial design

28 participants in 2 patient groups

presence of a vascular dysfunction

Description:

plasma

Treatment:

Biological: plasma

absence of vascular dysfunction

Description:

plasma

Treatment:

Biological: plasma