Characterization of Executive Functions and Patterns of Eye Movements in Children With Developmental Disabilities

Sheba Medical Center

Status

Unknown

Conditions

Developmental Coordination Disorder

Autistic Disorder

Attention Deficit Hyperactivity Disorder

Study type

Observational

Funder types

Other

Identifiers

NCT00716235

SHEBA-08-5185-LG-CTIL

Details and patient eligibility

About

The purpose of this study is to characterize the profile of executive functions and eye movements in several populations of children with developmental disabilities.

Full description

Abnormal Executive function (EF) profile was considered a major characteristic of Attention deficit / hyperactivity disorder (ADHD) and autism, and is frequently implicated in Developmental coordination disorder (DCD) children as well. The scientific literature implies that the EF profile among these three groups share some common abnormalities, but differ significantly in specific features. Abnormal EF profile may be a core feature of the developmental trajectory of each syndrome.

The fine measurement of eye movements may shed light on the underlying mechanisms of specific disorders, and point to abnormal attention, information processing, or motor organization. Gaze is an important component of social interaction. Eye contact and recognition of other's gaze direction are crucial to empathy assessment.

The current study will embark in the assessment of a wide range of EF in these populations and in a matched control group, as well as their relation to other important parameters such as daily function skills and comorbid neurobehavioral characteristics. It will also assess the pattern of eye movements in response to various visual stimuli in these populations. The main purpose is to characterize the similarities and differences of each of these populations, in terms of EF and eye movements.

Assessment methods:

Clinical parameters:

Intelligence tests (according to the child's age)
Communication: DSM-IV, ADOS, Stony Brook questionnaire
Motor / Coordination: Movement Advanced Battery for Children (M-ABC)
Attention: Conners Rating Scales - Revised (CRS-R 3rd ed.)
Sleep: Sleep habits questionnaire

Executive functions will be assessed using the following methods:

NEPSI-II
BRIEF questionnaire
Wisconsin Card Sorting Test
Tower of Hanoi

Eye movements will be measured using an infra-red video camera produced by ISCAN inc. the following visual stimuli will be presented:

Human faces presenting various emotions
Various objects
Saccade and anti-saccade tasks

Enrollment

160 estimated patients

Sex

All

Ages

4 to 10 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Age of 4-10 years
A medical diagnosis according to the relevant study group
Normal vision without glasses or contact lens.

Exclusion Criteria - clinical groups:

Intelligence Quotient below 70
A known brain damage
A known hearing impairment
Regular use of medications (except for psychostimulants)
Evidence for a known genetic syndrome
History of fetal CMV infection, birth asphyxia, major head injury or epilepsy

Exclusion Criteria - control group:

Intelligence Quotient below 70
Regular use of medications
Evidence for a neurological / psychiatric disorder, birth injury, developmental delay, head injury, or other medical disorders that affect the central nervous system
Family History - first degree) of autism, DCD, ADHD or other neurological/psychiatric disorder