Characterization of Left Atrial Substrate in Patients With Ventricular Arrhythmias (CLASS-VA)

Universitair Ziekenhuis Brussel

Status: Enrolling

Conditions: Atrial Remodeling

Treatments: Diagnostic Test: Left atrial electroanatomical mapping

Study type: Observational

Funder types: Other

Identifiers

NCT06425822

EC-2023-281

Details and patient eligibility

About

The goal of this observational study is to analyze the characteristics of left atrial electroanatomical maps in patients without a history of atrial fibrillation but with a high clinical risk of developing it, as indicated by the presence of structural heart disease or a CHA2DS2-VASc score ≥ 2 points. The study cohort will be compared to a historical cohort of patients with diagnosed atrial fibrillation in a propensity-matched fashion.

The main questions it aims to answer are:

• Are the left atrial electroanatomical changes a consequence or a precursor to the development of atrial fibrillation?
• Are the left atrial electroanatomical findings different between patients with atrial fibrillation and those at high risk of developing it?
• What is the prognostic impact of left atrial pathologic changes in patients without diagnosed atrial fibrillation in terms of cardiovascular outcomes?

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Absence of a prior history of atrial fibrillation or flutter.
• Patients presenting for ablation of any ventricular tachycardia related to structural heart disease or any ventricular arrhythmia with a CHA2DS2-VASc score ≥ 2.

Exclusion criteria

• Presence of thrombus in the left atrial appendage.
• Complications related to the index procedure.
• Insufficient quality of the left atrial electroanatomical map.

Trial design

50 participants in 1 patient group

Left atrial mapping group in patients without atrial fibrillation

Description:

Inclusion criteria: * Age ≥ 18 years old. * Absence of a prior history of atrial fibrillation or flutter. * Patients presenting for ablation of any ventricular tachycardia related to structural heart disease or any ventricular arrhythmia with a CHA2DS2-VASc score ≥ 2. Exclusion criteria: * Presence of thrombus in the left atrial appendage. * Complications related to the index procedure. * Insufficient quality of the left atrial electroanatomical map.

Treatment:

Diagnostic Test: Left atrial electroanatomical mapping