Characterization of Natural IL-6 Inhibition in Healthy Individuals (FIDI)

University of Copenhagen

Status: Enrolling

Conditions: Autoantibodies; Interleukin-6

Treatments: Other: Cycling test; Other: Oral Glucose Tolerance Test

Study type: Interventional

Funder types: Other

Identifiers

NCT05867524

H-20082776

Details and patient eligibility

About

The aim of the project is to investigate whether or not there are any difference in cardiometabolic outcomes in individuals with high or low levels of c-aAb against interleukin-6 (IL-6).

The study is the first to investigate individuals with extreme amounts of c-aAb levels against IL-6 and to contribute with knowledge on a possible new phenotype.

Enrollment: 40 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Fulfill Danish blood donor criteria
• Have extreme amounts of IL-6 c-aAb or matched as control (low amounts of IL-6 c-aAb)

Exclusion criteria

• Failure to fulfill Danish blood donor criteria

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

High IL-6 c-aAb

Experimental group

Description:

Individuals with top percentile IL-6 c-aAb

Treatment:

Other: Cycling test

Other: Oral Glucose Tolerance Test

Low IL-6 c-aAb

Experimental group

Description:

Individually matched controls with low IL-6 c-aAb

Treatment:

Other: Cycling test

Other: Oral Glucose Tolerance Test