Characterization of Obesity-related Cardiomyopathy Through Exploration of Human Atrial Trabeculae Contraction

University Hospital, Lille

Status

Completed

Conditions

Obesity

Heart Failure

Treatments

Other: functional tissu atrial analysis

Study type

Observational

Funder types

Other

Identifiers

NCT02384252

2012_09

2012-A01605-38 (Other Identifier)

Details and patient eligibility

About

The investigators aim to explore obese cardiomyopathy by studying contractile twitch force, sarcomere sensitivity to calcium and mitochondrial function in atrial myocardial samples of patients grouped according to their body mass index, i.e. normal weight, overweight and obese.

Full description

Obesity is associated with the development of heart failure, regardless of coronary artery disease or other comorbidities.

Right atrial samples obtained from patients undergoing cardiac surgery and presenting no sign of clinical cardiomyopathy will be grouped according to patient's body mass index. Atrial trabeculae will be explored to dissect out the respective contribution of (i) sarcoplasmic reticulum dysfunction (isometric twitch force contraction analysis), (ii) abnormal sarcomere sensitivity to calcium assessed in permeabilized fibers and (iii) mitochondrial dysfunction to intrinsec contractile dysfunction of myocardium in obese patients.

Enrollment

134 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patient schedulled for coronary artery bypass graft surgery or aortic valve replacement surgery with extracorporeal circulation
must be over 18 years of age
must be able to read and understand the consent form in French
must be in sinus rhythm at inclusion time

Exclusion criteria