Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome

US Department of Veterans Affairs (VA)

Status: Completed

Conditions: Irritable Bowel Syndrome

Treatments: Procedure: Viceral Perception Testing

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT00100425

CADE-ARCD2

Details and patient eligibility

About

The purpose of this study is to provide new information and to determine which kinds of brief, tolerable, experimental pain are affected by the drugs being studied in patients with irritable bowel syndrome, a disease that causes chronic abdominal pain. The effects of dextromethorphan, naloxone, and fentanyl on experimental pain stimuli will be tested in these studies to better understand what causes irritable bowel syndrome.

Sex: All

Ages: 18 to 72 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

• Patients with irritable bowel syndrome and healthy pain-free individuals (as controls) will be studied.
• No medical condition that would contraindicate use of dextromethorphan, fentanyl or naloxone.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Double Blind