Characterization of Peripheral Muscle Function in Patients With Non-small-cell Lung Cancer

C

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec

Status

Unknown

Conditions

Non-Small-cell Lung Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT01885754
20878

Details and patient eligibility

About

Rationale: With 1.6 million new cases diagnosed each year and 1.3 million deaths, lung cancer is the leading cancer-related death worldwide and it represents a pressing health issue. Patients with lung cancer are more likely to experience cachexia, a severe debilitating disorder causing fatigue, weight loss, muscle wasting and associated with reduced physical function, increased chemotherapy toxicity and reduced survival. This syndrome occurring in about 80% of advanced cancer patients is the direct cause of death in about 20% of cases. However, despite the importance of cachexia in lung cancer, its mechanisms ans its relation with muscle function and effort tolerance are still unknown. Aim: To explore muscle function, signaling pathways and its relationship to impaired functional capacity of patients with non-small-cell lung cancer(NSCLC); depending of whether they have cachexic state at diagnosis. Methods: This study will be conducted at the Institut universitaire de cardiologie et de pneumologie de Québec. 56 patients newly diagnosed of NSCLC will be recruited and separated whether or not they have a cachexic state. The evaluation will need two visits separated by 5 days. During the evaluation the following tests will be done: Anthropometric measures Level of daily physical activity Pulmonary function test Maximal incremental cardiopulmonary exercise test on ergocycle Endurance test on ergocycle Muscle function tests Magnetic stimulation Quadriceps biopsy

Enrollment

56 estimated patients

Sex

All

Ages

40 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Men and women with a primary lung cancer diagnosis

Exclusion criteria

  • Already have undertaken surgery, chemotherapy or radiotherapy treatment
  • Having an other cancer in the last five years
  • Taking anticoagulation therapy

Trial design

56 participants in 2 patient groups

Lung cancer patient with cachexia
Description:
Muscle lumbar area < 55cm2/m2 for men and < 39 cm2/m2 for women
Lung cancer patients without cachexia
Description:
Muscle lumbar area over 55cm2/m2 for men and 39 cm2/m2 for women

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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