Characterization of Phenotype and Genotype of Early Onset Enteropathies (IMMUNOBIOTA)

Imagine Institute

Status: Enrolling

Conditions: Inflammatory Bowel Disease

Treatments: Other: Biological sampling

Study type: Observational

Funder types: Other

Identifiers

NCT02614911

IMIS2014-01

Details and patient eligibility

About

This study has been set up in order to characterize phenotypes and genotypes of patients with early onset enteropathies.

In that goal, Investigators will collect biological samples (mainly blood) of patients suffering from early onset enteropathies and their healthy relatives.

Full description

This study specifically aims at the genetic analysis of early onset enteropathies with the goal in mind to delineate human pathways necessary to maintain intestinal homeostasis despite the considerable density of microbes colonizing the distal part of the human intestine.

Enrollment: 1,445 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Main Inclusion Criteria:

• Severe chronic enteropathy
• Patients developing their first symptoms within the first 6 years of life and, in priority within the first two years of life, or patients with a disease of later onset, in case of a familial history suggestive of inherited mutations notably in families comprising several affected members
• OR : Be a patient's relative, even if presenting with enteropathy of later onset.

Main Exclusion Criteria:

• Subject having participated to any therapeutical clinical study in the 30 days preceding the inclusion in this study,

Trial design

1,445 participants in 2 patient groups

Sick patients

Description:

Biological sampling of blood for all patients. Biological sampling of saliva, biopsies (skin and endoscopic), feces, for some patients

Treatment:

Other: Biological sampling

Healthy relatives

Description:

Biological sampling of blood for all healthy relatives

Treatment:

Other: Biological sampling