Characterization of Retinal Microvascular and FAZ Changes in Ischemic Stroke and Its Different Types

Peking University

Status: Unknown

Conditions: Ischemic Stroke

Treatments: Device: Optical Coherence Tomography Angiography

Study type: Observational

Funder types: Other

Identifiers

NCT05243849

OCTA

Details and patient eligibility

About

The study aimed to access the microvascular changes in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in patients with ischemic stroke and its different types using optical coherence tomography angiography.

Full description

Investigators used OCTA to quantitatively access the retinal microvasculature of SCP and DCP, aiming to detect the geometry changes of retinal microvasculature and FAZ in ischemic stroke patients and its different types.

Enrollment: 100 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients who were diagnosed with ischemic stroke by MRI were scheduled for an OCTA examination. The diagnosis of ischemic stroke was obtained from previous diagnostic reports or electronic medical records, according to the diagnostic criteria from the Trial of Org 10172 in Acute Stroke Treatment (TOAST).

Exclusion criteria

1. Retinal diseases or diseases affecting vessel structure in fundus photography, including age-related maculopathy; diabetic retinopathy, central serous chorioretinopathy, retinal pigment epithelial detachment and glaucoma); poor cooperation in ophthalmic examinations; high refractive error (>+6.00 D or <-6.00 D Spherical Equivalent); low-quality OCTA images (signal strength index < 6/10). Inclusion criteria for healthy controls were no history of ischemic stroke or other neurological and ocular diseases.

Trial design

100 participants in 2 patient groups

Ischemic Stroke

Description:

The diagnosis of ischemic stroke was obtained from previous diagnostic reports or electronic medical records, according to the diagnostic criteria from the Trial of Org 10172 in Acute Stroke Treatment (TOAST).

Treatment:

Device: Optical Coherence Tomography Angiography

Control

Description:

Inclusion criteria for healthy controls were no history of ischemic stroke or other neurological and ocular diseases.

Treatment:

Device: Optical Coherence Tomography Angiography