Characterization of the Genetic Profile of Type 2 Endometrial Carcinoma in Martinique (ENDO-NGS-MQ)

University Hospital Center of Martinique

Status

Completed

Conditions

Endometrial Neoplasms

Treatments

Diagnostic Test: Intervention Arm

Study type

Observational

Funder types

Other

Identifiers

NCT03766672

2018-A02091-54 (Other Identifier)

18_RIPH2_15

Details and patient eligibility

About

In Martinique, about 33 new cases are diagnosed per year, with a high incidence rate of type 2 endometrial carcinoma which has a poor prognosis with few therapeutic options. Although targeted therapies are used in many types of cancer, they are still possible a minority of patients. In current practice, endometrial cancers do not benefit these therapies. Characterization of the molecular mechanisms involved in the genesis of type 2 endometrial carcinoma could help to identify biomarkers predictive of a response to targeted therapies. We propose to identify the genetic profile of type 2 endometrial carcinomas in Martinique.

Full description

Type 2 endometrial carcinomas are often diagnosed at advanced stages, with an high risk of metastatic recurrence and death even when diagnosed at early stages. They also have few therapeutic options. The Characterize the mutations responsible of cancer development has led to develope "precision medicine" that targets "actionable genes" by a drug. This concept of actionable mutation refers to a change in the DNA molecule that can predict the response to a drug defined as targeted therapy. Although targeted therapies are used in many types of cancer, they still target a minority of patients. Some tumor sites still do not benefit from these treatments. Specifically, type 2 endometrial cancers that have poor prognosis with few therapeutic options. The characterization of molecular mechanisms, by Next Generation Sequencing (NGS), involved in the carcinogenesis of endometrial cancers, particularly type 2 cancers, should allow the identification of predictive biomarkers for response to certain targeted therapies.

Enrollment

30 patients

Sex

Female

Volunteers

No Healthy Volunteers

Inclusion criteria

Major subject living in Martinique with the following characteristics :
- Patients with type 2 endometrial cancer, with anatomopathological confirmation
- Affiliate or beneficiary of french social security.
- Free, informed with a written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any research required by the research).

Exclusion criteria