Characterization of the Gut Microbiota Composition and Activity After Three Weeks of Chitin-glucan Supplementation

Nathalie Delzenne

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: Chitin-glucan fiber

Study type

Interventional

Funder types

Other

Identifiers

NCT03505177

FiberTAG2

Details and patient eligibility

About

The aim of this research study is to characterize gut microbiota composition and activity after a daily supplementation of 4.5 g of chitin-glucan during 3 weeks. For this purpose, a monocentric longitudinal intervention study without control will be performed. Fecal microbiota composition and fecal concentrations of gut microbiota-derived metabolites (bile acids, conjugated-polyunsaturated fatty acids and short-chain fatty acids) will be measured. In addition, during ten hours following the ingestion of a test meal rich in fibers, the kinetic of production of H2, methane and volatile compounds exhaled from breath will be evaluated.

Enrollment

17 patients

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Woman or man, aged of 18 to 40 years
Body mass index (BMI) between 18 and 25 kg/m2
In good general health as evidenced by medical history and physical examination
Non-smoker
Caucasian
H2 - producer
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study

Exclusion criteria

Subjects presenting gastro-intestinal disorders such as ulcers, diverticulitis and inflammatory bowel diseases
Subject presenting allergy or food intolerance (lactose, gluten,...)
Subjects with psychiatric problems and/or using antipsychotics
Current or recent (< 4 weeks) intake of antibiotic, probiotic, prebiotic, fiber supplement, and/or any product modulating gut transit
Feeding particular diet such as vegetarian diet or hyper protein diet
Chronic intake of drug, excepted contraceptive drug
Pregnant or lactating woman or woman who did not use highly effective contraception
Subjects who drink more than 3 glasses of alcohol per day (> 30 g of alcohol per day)
Subjects having participated to another clinical trial two weeks before the screening test visit
Subjects presenting an allergy or intolerance to one component of the product tested