Characterizing Hemorrhage in Acute Spinal Cord Injury With MRI (CHASM)

University of British Columbia

Status

Enrolling

Conditions

Traumatic Spinal Cord Haemorrhage

Treatments

Procedure: Magnetic resonance imaging (MRI)

Study type

Interventional

Funder types

Other

Other U.S. Federal agency

Identifiers

NCT04758377

H20-03585

Details and patient eligibility

About

The study is designed to determine whether hemorrhage within the injured spinal cord is influenced by mean arterial pressure (MAP) augmentation with vasopressors and by venous thromboembolism (VTE) prophylaxis with anticoagulants in the first two weeks following a traumatic spinal cord injury (tSCI).

Full description

This will be a single-center prospective observational study of patients with an acute cervical traumatic spinal cord injury

Enrollment

24 estimated patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Acute tSCI injury involving bony spinal levels between C0 and T1
Baseline Asia Impairment Scale (AIS) grade of A, B, or C
Admission to study site within 24 hours of injury
Male or female age 19 or older
Able and willing to provide informed consent

Exclusion criteria

Pathological fracture due to metabolic condition or neoplasia
Spinal cord injury due to infection
Presence of pacemaker, aneurysm clip or other device which is a contraindication to MRI
BMI > 40 and unable to fit within the MRI scanner
Multiple life threatening injuries (ISS >16) that make transport to MRI not in the patient's best interest
Any condition that, at the time of admission, prevents a complete ISNCSCI assessment from being performed