Chart Review of Patients Undergoing Ketamine Treatments for Depression

Sunnybrook Health Sciences Centre

Status: Completed

Conditions: Depression - Major Depressive Disorder

Treatments: Drug: ketamine hydrochloride

Study type: Observational

Funder types: Other

Identifiers

NCT07099235

6828

Details and patient eligibility

About

The Ontario Ketamine and Infusion Centre (OKIC) is a CPSO-certified Level-II OHP and an outpatient centre for intravenous ketamine treatments for treatment-resistant depression. This retrospective, observational study aims to conduct a chart review on patients receiving ketamine in a naturalistic setting to develop our understanding of ketamine as an interventional approach for treatment-resistant depression.

Enrollment: 250 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18
• Able to provide informed consent
• Patient diagnosed with treatment-resistant depression
• Outpatient recommended and approved by psychiatrist for ketamine treatment
• Individuals who have previously received ECT, rTMS or any other neuromodulation can also receive ketamine

Exclusion criteria

• History of psychosis/comorbid psychiatric disorders/psychotic depression/dissociative syndromes, significant personality disorder, as clinically assessed by psychiatrist
• Using non-prescribed substance (e.g., cannabis) or alcohol use within the preceding 48 hours of treatment
• History of substance misuse and/or dependence, including chronic alcohol abuse
• Previous ketamine use
• Acute dementia/delirium
• Pregnancy/breastfeeding
• Previous sensitivity to ketamine or related compounds
• Unstable medical condition which may require anesthesia consult
• History of elevated intracranial pressure or cerebrovascular accident
• Recent (within 6 weeks) major cardiovascular event (such as myocardial infarction)

Trial design

250 participants in 1 patient group

Treatment-resistant Major Depressive Disorder (MDD); DSM-5 Diagnosis of MDD

Treatment:

Drug: ketamine hydrochloride