Chatbot Utilization for Pedigree Creation and Cancer Risk Assessment in Cancer Genetic Counseling

Roswell Park Comprehensive Cancer Center

Status

Enrolling

Conditions

Hereditary Malignant Neoplasm

Hereditary Breast Carcinoma

Treatments

Other: Text Message -based Navigation Intervenion

Other: Artificial Intelligence based Intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT07887620

I-4840126

Details and patient eligibility

About

This clinical trial studies whether a chatbot can be used to help collect medical history and perform cancer risk assessment among patients undergoing cancer genetic counseling. With the improved cost of genetic testing and growing utilization of genetics in cancer care and risk assessment, there is growing pressure placed on certified genetic counselors. To address this issue, many have turned to artificial intelligence (the branch of computer science that deals with writing computer programs that can solve problems creatively) for practical solutions to re-distribute the workload of certified genetic counselors. The chatbot in this trial uses artificial intelligence technology to analyze information provided by the patient during a phone call. The chatbot then generates a family history summary, family tree (pedigree), and cancer risk related assessments, which may help redistribute the workload for the certified genetic counselor and ultimately make genetic counseling more accessible. Using a chatbot may be helpful in collecting medical history and determining cancer risk assessment among patients undergoing cancer genetic counseling.

Full description

PRIMARY OBJECTIVE:

I. To assess the sensitivity and specificity of a chatbot's determination of meeting National Comprehensive Cancer Network (NCCN) criteria for germline genetic testing compared to a certified genetic counselor's determination

SECONDAY OBJECTIVES:

I. To assess the reliability and accuracy of a chatbot-generated cancer-focused family pedigree as determined by a certified genetic counselor.

II. To determine the sensitivity and specificity of a chatbot-generated Tyrer-Cuzick determination of breast cancer risk.

III. To evaluate the proportion of patients in a genetic counseling clinic population with greater than 20% lifetime risk of breast cancer and/or criteria met for germline genetic testing.

IV. To evaluate patient satisfaction using a chatbot for family history collection and breast cancer risk assessment.

V. To evaluate provider satisfaction with use, accuracy, and clinical workflow of chatbot-derived data.

OUTLINE:

Patients receive a text message with chatbot phone number at baseline. Patients then complete a phone call with the chatbot over 10-20 minutes consisting of a structured, genetics-specific interview and receive a chatbot generated provider summary, pedigree/structured data, NCCN flag, and Tyler-Cuzick score, which are routed to clinical team up to 21 days before scheduled genetics appointment.

Enrollment

129 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

PATIENT PARTICIPANTS: Age 18 years or greater
PATIENT PARTICIPANTS: Scheduled as a new patient appointment to see a certified genetic counselor at the Roswell Park Comprehensive Cancer Center (either in person or for a virtual appointment)
PATIENT PARTICIPANTS: Written and spoken fluency in English
PATIENT PARTICIPANTS: Able to understand the consenting process and willing to participate in the study
GENETIC COUNSELOR PARTICIPANTS: Any genetic counselor who sees patients for initial genetics consultation at Roswell Park Comprehensive Cancer Center is eligible to participate in the study

Exclusion criteria

Prior germline genetic testing for a hereditary cancer predisposition
First or second-degree family member with a known pathogenic variant, likely pathogenic variant, or variant of uncertain significance in a gene associated with cancer predisposition
Scheduled to see a genetic counselor who has not give