Checkpoint Inhibitors in Patients With Solid Tumors: a Retrospective Real-world Study

Nanjing Medical University

Status: Enrolling

Conditions: Immunotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT05719324

2022-SR-219

Details and patient eligibility

About

This is a retrospective clinical study aimed at observing and evaluating the effectiveness and safety of checkpoint inhibitors in the treatment of patients with solid tumors in actual clinical applications. To explore predictors of efficacy patients with unresectable solid tumors receiving checkpoint inhibitors and develop and further validate predictive models.

Full description

The clinical data of patients with unresectable solid tumors were collected retrospectively, who received two or more cycles of checkpoint inhibitor therapy. The progression-free survival (PFS), overall survival (OS) and related adverse reactions of the patients were followed up. To screen prognostic factors, develop predictive models and visualize them as nomograms.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years old and gender is not limited.
• Patients with unresectable solid tumors confirmed by pathology or histology.
• Patients received checkpoint inhibitor therapy for 2 cycles or more.

Exclusion criteria

• Have a history of immunodeficiency, or suffer from other acquired or congenital immunodeficiency diseases, or have a history of organ transplantation.
• Pre-existing thyroid dysfunction that cannot be maintained within the normal range even with medical treatment.
• Pregnant or breastfeeding women.
• Those who have a history of psychotropic drug abuse and cannot quit or have mental disorders.
• The investigator judges that other conditions are not suitable for inclusion in the study.