Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM

Shandong University

Status

Not yet enrolling

Conditions

Colorectal Neoplasms Malignant

Lymph Node Excision

Chemoradiotherapy

Treatments

Procedure: Radical surgery with PALND

Procedure: Radical surgery without PALND

Study type

Interventional

Funder types

Other

Identifiers

NCT05129774

V123456

Details and patient eligibility

About

In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%. Currently, there has been no standard treatment strategy for this situation. The present trial is designed to evaluate the safety and efficacy of para-aortic lymph node dissection for left-sided colon and rectal cancer with synchronous para-aortic lymph node metastasis

Enrollment

40 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age at enrollment is ≥ 18 and ≤ 75 years
ECOG PS 0-1
histologically confirmed left-sided colon and rectal carcinoma
synchronous para-aortic lymph node metastases confirmed by PET-CT, and located below the level of renal veins and above the bifurcation of iliac artery
patients potential to receive surgery and achieve no evidence of disease (NED)
able to tolerate surgery
providing written informed consent

Exclusion criteria

local invasion or distant metastasis other than para-aoritc lymph nodes
history of other malignant tumor
coupled with severe systematic diseases (recent myocardial infarction, cardiomyopathy, or acute pulmonary infection)
emergency surgery